Fragile takes place in the near future, in a world that has lost its population. You play as Seto, a young boy searching through the abandoned cities and facilities of this world, trying to learn the truth behind the disappearance of all the people, and to find someone to keep him company. In addition to exploration, Seto has to deal with ghosts who appear in the ruins.

Players will be able to explore a dark and abandoned world with the aid of their Wii Remote that functions as a flashlight and as a proximity sensor to hunt down invisible ghosts. The cinematic presentation, joined with an emotional soundtrack, bring the tale of a lonely and lost individual to life as players encounter memorable characters and discover the back story behind scavenged objects that provide insight on people's last days before the apocalypse.